| CAS No.: | 70288-86-7 |
|---|---|
| Formula: | C48h74o14 |
| EINECS: | 274-536-0 |
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| Product name | Ivermectin |
| CAS number | 70288-86-7 |
| Purity | >99% |
| Transport Package | 1kg/Drum or Customized |
| Appearance | White Powder |
| Storage | After reconstitution store at 2 ºC- 8ºC |
Ivermectin is sometimes used as an acaricide in reptiles, both by injection and as a diluted spray. While this works well in some cases, care must be taken, as several species of reptiles are very sensitive to ivermectin. Use in turtles is particularly contraindicated.
| Melting Point | 155 °C |
|---|---|
| Molecular Formula | C48H74O14 |
| Molecular Weight | 875.09300 |
| Exact Mass | 874.50800 |
| PSA | 170.06000 |
| LogP | 5.60140 |
| Storage condition | 2-8°C |
| Water Solubility | H2O: ≤1.0% KF |
| Tests | Specification | Results | |
| Appearance | White or yellowish-white crystalline powder, slightly hygroscopic. | Yellowish-white crystalline powder, slight hygroscopic. | |
| Solubility | Practically insoluble in water, soluble in alcohol. | Qualified | |
| Identification | IR | Corresponds to that of CRS standard | Qualified |
| HPLC | The retention time for H2Bla and H2Blb in the chromatogram obtained with the test solution corresponds to those of standard preparation | Qualified | |
| Appearance of solution | Clear and not more intensely colored than BY? | Clear | |
| Specific optical rotation (anhydrous and solvent-free substance), ° | -20--17 | -17.9 | |
| Related substances (%) | Individual impurity(RRT 1.3-1.5)≤2.5 | I-l:<0.05 K:2.1 | |
| Any other impurity ≤ 1 | C:0.06 A:0.57 J:0.14 H:0.39 D:<0.05 F:<0.05 E:0.36 1-2:0.19 |
||
| Total ≤5 | 3.8 | ||
| Disregard limit: 0.05 | |||
| Ethanol and Formamide (%) | Ethanol ≤5.0 | 3.9 | |
| Formamide≤3.0 | 2.5 | ||
| Catalyst (ug/g) | ≤1 | <1 | |
| Water (%) | ≤1.0 | 0.26 | |
| Sulphated ash (%) | ≤0.1 | 0.07 | |
| Heavy Metal (%) | ≤0.002 | <0.002 | |
| Assay (%) (HPLC, on dry basis) | H2Bla/(H2Bla +H2Blb)≥90.0 | 97.7 | |
| 95.0≤H2Bla +H2Blb≤ 102.0 | 96.7 | ||
| Conclusion | Complies with the requirements of EP10.0 | ||
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